Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production
- Resource Type
- article
- Authors
- Aurora Scrivo; Patrice Codogno; Pascale Bomont
- Source
- Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
- Subject
- Science
- Language
- English
- ISSN
- 2041-1723
Membrane elongation is fundamental to autophagy and is controlled by an ubiquitin-conjugating cascade orchestrated by ATG16L1. Here, the authors identify that the E3 ligase Gigaxonin regulates autophagosome formation by controlling ATG16L1 turnover.