The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye
- Resource Type
- article
- Authors
- Anne Wolf; Marc Herb; Michael Schramm; Thomas Langmann
- Source
- Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
- Subject
- Science
- Language
- English
- ISSN
- 2041-1723
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. Here, the authors show that microglia-specific deletion of TSPO and chemical inhibition of TSPO prevent neuroinflammation and vascular damage in a mouse model of AMD.