Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy
- Resource Type
- article
- Authors
- Chi Yan; Ann Richmond
- Source
- Molecular Cancer, Vol 20, Iss 1, Pp 1-5 (2021)
- Subject
- CD40
Cancer
Nevi
Melanoma
PD-1/PD-L1
CTLA4
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
- Language
- English
- ISSN
- 1476-4598
Highlights CD40 expression correlates with the type I anti-tumor response and better survival. Pan-cancer bioinformatics characterization reveals reduced CD40 expression in 11 cancer types, including RAS mut melanoma compared to nevi. RAS mutation correlates with reduced CD40 expression in malignant melanoma. CD40 expression is associated with better response to immune checkpoint blockade therapy in melanoma.