Gene therapy for cystic fibrosis: new tools for precision medicine
- Resource Type
- article
- Authors
- Jin-A Lee; Alex Cho; Elena N. Huang; Yiming Xu; Henry Quach; Jim Hu; Amy P. Wong
- Source
- Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-15 (2021)
- Subject
- Cystic fibrosis
Stem cells
Lung
Organoids
CFTR
Alternative chloride channels
Medicine
- Language
- English
- ISSN
- 1479-5876
Abstract The discovery of the Cystic fibrosis (CF) gene in 1989 has paved the way for incredible progress in treating the disease such that the mean survival age of individuals living with CF is now ~58 years in Canada. Recent developments in gene targeting tools and new cell and animal models have re-ignited the search for a permanent genetic cure for all CF. In this review, we highlight some of the more recent gene therapy approaches as well as new models that will provide insight into personalized therapies for CF.