FAK family kinases: The Yin and Yang of cancer cell invasiveness
- Resource Type
- article
- Authors
- Alessandro Genna; Hava Gil-Henn
- Source
- Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
- Subject
- fak
pyk2
focal adhesions
invadopodia
invasion
migration
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
- Language
- English
- ISSN
- 2372-3556
23723556
Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular matrix invasion. Our recent findings present Pyk2 and FAK as novel mediators of breast cancer invasiveness and as potential targets for blocking breast cancer metastasis.