Revealing key role of T cells in neurodegenerative diseases, with potential to develop new targeted therapies
- Resource Type
- article-commentary
- Authors
- Zhang, Haofuzi; Jiang, Xiaofan
- Source
- Translational Neuroscience. 14(1)
- Subject
- T cell
neurodegenerative disease
therapy
Commentary
- Language
- English
- ISSN
- 2081-6936
David M. Holtzman and his team at the University of Washington School of Medicine have made breakthroughs in their research on neurodegenerative diseases. They discovered that the infiltration of T cells into the brain, instigated by activated microglia, is a critical factor in the progression of tauopathy. The groundbreaking findings were published in Nature on March 8, 2023. This research delineates a pivotal immune hub linked to tauopathy and neurodegeneration; a complex interplay involving activated microglia and T cell responses. This discovery could potentially become a target for developing therapeutic interventions for Alzheimer’s disease and primary neurodegeneration.