Ciprofloxacin (CIP) is one of the fluoroquinolones developed to fight several bacterial infections. CIP abuse and its low biodegradability cause water contamination that leads to the production of CIP-resistant bacteria. A high concentration of CIP, including other quinolones, causes harmful effects on fish, humans, bacteria, algae, and protozoa. Adsorption has been preferred over other removal methods. The superior properties of ZIF-8 over other MOFs have made it a promising adsorbent for the removal of CIP from an aquatic environment. However, ZIF-8 suffers from its inability to recover from an aqueous environment and the related mass transfer problems. These limitations have been overcome by the synthesis of ZIF-8-based composites. ZIF- 8 composites have been proved as efficient catalysts for the adsorption of CIP from water. They offer a higher number of adsorption sites for CIP than ZIF-8. The adsorption of CIP over ZIF-8-based composites occurs via the interaction between the adsorbent and CIP. They interact through hydrogen bonding, electrostatic interaction, complexation, pi-pi interaction, and hydrophobic interaction. The pH of the solution contributes significantly to the type of interaction taking place between the composite and CIP. These composites can be used in the practical application of decontamination of wastewater because of their high regeneration and recycling ability.