In-Situ Measurements of the Physiological Parameters in Lab-on-Chip Systems
- Resource Type
- research-article
- Authors
- Bakhchova, Liubov; Steinmann, Ulrike
- Source
- tm - Technisches Messen. 89(s1):61-65
- Subject
- Optischer Sensor
TEER-Elektroden
Organ-on-a-Chip
Lab-on-Chip
optical sensor
TEER electrodes
organ-on-achip
lab-on-chip
Beiträge
- Language
- German
- ISSN
- 2196-7113
0171-8096
There is a growing interest in integrating biosensors into lab-on-chip systems. Sensor integration in the cell culture systems allows direct measurements of the biological and physiological parameters while the cells grow. It requires a special design of the microfluidic chip and microstructuring of the conductive materials. In this work, we present two approaches for in-situ measurements of the physiological parameters. The first approach is an integration of a commercial optical sensor for oxygen level detection. The second solution is a self-designed and self-manufactured transepithelial resistance (TEER) sensor for cell confluence measurements. Both sensors were integrated in a flexible microfluidic chip based on Polydimethylsiloxane (PDMS).