Chronic pain is a complex phenomenon affecting all dimensions of life: mental, social and spiritual not less than physical. Whilst treating this group of patients, this must be taken into account. We examined which conditions influence this phenomenon in German-speaking Switzerland. At five study centres, 5 interprofessional focus groups compromising a total of 34 health care professionals were interviewed regarding their awareness of spiritual concerns and needs within this patient group and how these may be accommodated in the therapeutic process. A thematic analysis revealed three key issues: the relevance of spiritual dimensions in multimodal pain therapy, action-guiding convictions, and spiritual care skills. Respondents were generally open-minded about spiritual issues. From their point of view, integrating spiritual concerns and needs into the treatment process adds value to the quality of care for this patient group. Consistent implementation, however, poses some so far unresolved challenges. Qualification and institutional support are required to provide appropriate room to spiritual care.