Autophagy:a double-edged sword for neuronal survival after cerebral ischemia
- Resource Type
- Academic Journal
- Authors
- Wenqi Chen; Yinyi Sun; Kangyong Liu; Xiaojiang Sun
- Source
- 中国神经再生研究(英文版) / Neural Regeneration Research. (12):1210-1216
- Subject
- nerve regeneration
autophagy
lysosome
autophagosome
neuron
cerebral ischemia
signaling pathway
apoptosis
necrosis
survival
NSFC grant
neural regeneration
- Language
- Chinese
- ISSN
- 1673-5374
Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether acti-vation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.