阿尔茨海默病(Alzheimer's disease,AD)是以记忆障碍及多种认知能力退化为主的神经退行性疾病.针刺干预AD具有潜在的疗效,但起效机制尚未明确.血氧水平依赖功能磁共振成像(BOLD-fMRI)因精准定位AD异常脑区并监测分析功能活动的独特优势,为揭示AD脑效应研究提供了技术支持.研究发现响应脑区及脑网络功能活动的异常变化与AD的发生发展密切相关.已有的研究表明针刺可通过改善AD患者多个认知相关脑区和脑网络的功能损害发挥治疗作用,这可能是针刺干预AD的脑功能机制.本文基于BOLD-fMRI技术,围绕AD常用的数据分析方法、AD发病的脑功能机制及针刺干预AD的脑效应研究3个方面进行阐述.以期为进一步探讨针刺干预AD脑效应研究提供参考.
Alzheimer' disease(AD)is a neurodegenerative disorder characterized by memory impairment and multiple cognitive deterioration.Acupuncture intervention in AD has potential efficacy,but the mechanism of onset is not clear.Blood oxygen level-dependent functional magnetic resonance imaging(BOLD-fMRI)has the unique advantages of accurately locating abnormal AD brain areas and monitoring and analyzing functional activities,providing technical support for the study of AD brain effects.It have found that abnormal changes in functional activity in response to brain regions and brain networks are closely related to the development of AD.Previous studies have shown that acupuncture can exert therapeutic effects by improving the functional impairment of multiple cognitive-related brain regions and brain networks in AD,which may be the mechanism of brain function in AD.Based on BOLD-fMRI technology,this paper elaborates on three aspects:commonly used data analysis methods of AD,the brain function mechanism of AD pathogenesis,and the brain effect study of acupuncture intervention in AD.In order to provide a reference for further exploring the brain effect of acupuncture intervention in AD.