肥胖是心血管疾病的重要独立危险因素,可增加心血管疾病的风险,长期肥胖可引起心脏功能紊乱,发展为肥胖性心肌病,严重者可导致心力衰竭,研究更安全有效的肥胖性心肌病治疗方法迫在眉睫.近年来基于肥胖人群的研究表明,GLP-1 RA可有效降低肥胖患者心血管疾病发病的风险,可能通过抗氧化应激、抑制炎性反应、改善微循环功能障碍以及抵制心肌纤维化等多个方面发挥作用.
Obesity is an important independent risk factor for cardiovascular disease,which can increase the risk of cardiovascular disease,long-term obesity can cause cardiac dysfunction,develop into obese cardiomyopathy,and in se-vere cases,it can lead to heart failure,so it is urgent to study safer and more effective treatments for obese cardiomyopa-thy.Recent studies based on obese people have shown that GLP-1 RA can effectively reduce the risk of cardiovascular dis-ease in obese patients,and may play a role in antioxidative stress,inhibition of inflammatory response,improvement of mi-crocirculatory dysfunction,and resistance to myocardial fibrosis.