Objective:To preliminarily explore the effect of auxiliary ventilator treatment of Type 2 diabetes mellitus with obstructive sleep apnea hypopnea syndrome (OSAHS).Method:A total of 50 OSAHS patients with Type 2 diabetes mellitus treated in Guang’anmen Hospital from September, 2014 to May, 2015 included experimental group (n=25) who received ventilator therapy and control group (n=25), and both groups received 3 months of treatment.Results:Compared with control group, AHI (20.5±9.4(h) vs 57.6±16.1(h)), LSPO (90.8±12.3(%) vs 76.2±14.8(%)) in the experimental group were significantly improved after assisted ventilation therapy.Conclusions: In addition to controlling plasma glucose by conventional drugs, it is also very important for OSAHS patients with type 2 diabetes to actively use assisted ventilation therapy to improve hypoxia.