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요약정보
司丙红霉素安全性药理学研究 / The safety evaluation of erythromycin stinoprate
Resource Type
Academic Journal
Authors
潘经媛
;
邱银生
;
严汉池
;
凌飒
;
PAN Jing-yuan
;
QIU Yin-sheng
;
YAN Han-chi
;
LING Sha
Source
中国新药杂志 / CHINESE JOURNAL OF NEW DRUGS
. 15(4):276-280
Subject
司丙红霉素
安全性药理
心血管系统
呼吸系统
神经系统
Language
Chinese
ISSN
1003-3734
Online Access
Find it @ DONGA
초록
目的:观察司丙红霉素对大鼠心血管、呼吸系统和小鼠中枢神经系统的影响.方法:健康SD大鼠分别按体重随机分为低、中、高3个剂量组和溶媒对照组.给药组分别从十二脂肠给予司丙红霉素75,150,300 mg·kg-1,对血压、心电图(ECG)、呼吸频率及呼吸幅度进行观察.小鼠实验分低、中、高3个剂量组及溶媒对照共4个组,分别灌胃给予司丙红霉素75,150,300 mg·kg-1,对动物一般活动和睡眠时间进行观察.结果:司丙红霉素刎300 mg·kg-1剂量组使大鼠心率下降,对舒张压、收缩压、ECG之QRS时间、ST段、T波、QT间期、呼吸频率及呼吸幅度无明显的影响;对小鼠一般活动和睡眠时间无明显影响.75,150 mg·kg-1剂量组对大鼠、小鼠各项指标无明显影响.结论:司丙红霉素300 mg·kg-1对心血管系统有一定影响,可使大鼠心率下降.
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