在疾病进展等多种应激原的刺激下,肿瘤患者极易发生慢性应激.慢性应激通过持续激活交感神经系统和下丘脑-垂体-肾上腺轴,导致机体神经内分泌功能紊乱和肠道菌群失调,影响肿瘤进展过程中的多个步骤.对患者进行心理干预以及药物治疗等,可能会有效改善患者生存质量,提高抗肿瘤治疗效果.文章就慢性应激对肿瘤发生发展的影响及相关干预措施作一综述.
Under the stimulation of various stressors such as disease progression,cancer patients are prone to chronic stress.Chronic stress can continuously activate the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis,leading to neuro-endocrine dysfunction and imbalance ofintestinal flora,and affecting multiple steps in the process of tumor progression.Psychological intervention and drug therapy may effectively improve the quality of life of patients and improve the effect of anti-tumor therapy.This article reviews the effects of chronic stress on the occurrence anddevelopment of tumor and the relevant intervention measures.