目的:研究 CCR7在人骨肉瘤组织中的表达情况,并探讨 CCR7表达与临床病理之间的关系。方法:收集临床50例骨肉瘤组织及20例骨软骨瘤组织,使用免疫组织化学方法检测其 CCR7的表达水平。结果:CCR7在骨肉瘤组织和骨软骨瘤组织中的阳性表达率分别为80.00%和15.00%。CCR7阳性表达和骨肉瘤肿瘤大小及转移密切相关(P <0.05),而与年龄、性别、临床分期及组织学分型没有明显关系(P >0.05)。结论:骨肉瘤组织中 CCR7高表达预示着其在肿瘤增长和肿瘤转移可能起到一定的作用。因此 CCR7可能会成为临床上治疗骨肉瘤一个新的靶点。
Objective:To investigate the expression of CCR7 in osteosarcoma and discuss the underlying relation-ship between the expression and clinical significance.Methods:Immunohistochemical staining was used to measure the expression of CCR7 in 50 cases of osteosarcoma tissues and 20 cases of osteochondroma tissues.Results:The posi-tive expression rates of CCR7 were 80.00% and 15.00% respectively in 50 cases of osteosarcoma tissues and 20 ca-ses of osteochondroma tissues.The CCR7 expression were related to the size of the tumor(P <0.05)and the metasta-sis of osteosarcoma(P <0.05).There was no evident link between CCR7 expression and age,gender,clinical stages and histological type(P >0.05).Conclusion:The highly expressed CCR7 in osteosacroma indicates that CCR7 may play a significant role in tumor progression and metastasis.Therefore,CCR7 could be an ideal target for the treatment of osteosarcoma.