胶质瘤是成人最常见的原发性颅内肿瘤,其中高级别胶质瘤患者具有生存期短、预后差的特点.高级别胶质瘤的诊断、治疗、疗效评价及预后预测对于改善患者生存有着重要意义.传统增强磁共振成像在定义肿瘤边界、鉴别肿瘤进展与治疗相关改变等方面存在着不足,因此,将氨基酸PET尤其是18 F-FET PET纳入高级别胶质瘤的诊治过程已得到广泛共识.本文对近年来18 F-FET PET在成人高级别胶质瘤的诊断、治疗中的研究新进展进行阐述.
Gliomas are the most common primary intracranial tumors in adults,among which high-grade glioma patients are characterized by short survival and poor prognosis.The diagnosis,treatment,evaluation of effective treatments,and prognosis prediction of high-grade gliomas are of great significance for improving pa-tient survival.Conventional enhanced magnetic resonance imaging has deficiencies in delineating tumor extent,identifying tumor progression and treatment-related changes.Therefore,there is a broad consensus to incorporate amino acid PET,and 18 F-FET PET inparticular,into the diagnostic and therapeutic process of high-grade gliomas.In this article,we review the new research progress of 18 F-FET PET in the diagnosis and treat-ment of adult high-grade glioma in recent years.