目的 探究火针放血联合自拟除湿消痤汤治疗马拉色菌毛囊炎的疗效及作用机理.方法 按标准筛选符合的病例随机分为对照组(自拟除湿消痤汤治疗)和治疗组(自拟除湿消痤汤联合火针放血治疗),记录2组治疗前后症状及皮损变化评分、真菌检查、不良反应等指标.结果 经治疗后,治疗组的显效率为88.89%,对照组的显效率为65.38%,组间疗效结果对比有显著性差异(P<0.05).2组自觉症状明显改善,组内对比均有显著性差异(P<0.01),组间对比治疗组的改善情况优于对照组(P<0.05).治疗组与对照组真菌清除率组内对比有显著性差异(P<0.05).治疗组与对照组均无出现明显皮肤局部反应及可能出现的其他不良反应(P>0.05).结论 火针放血联合除湿消痤汤治疗马拉色菌毛囊炎的疗效显著,且能抑制真菌感染,无明显不良反应,安全性高,其作用机制可能与局部皮肤炎症水平下降及微循环改善等相关.
Objective To explore the therapeutic effect and mechanism of fire needle bloodletting therapy combined with self-made Chushi Xiaocuo decoction in the treatment of Malassezia folliculitis.Methods According to the criteria,the eligible cases were randomly selected and divided into a control group(treated with self-made Chushi Xiaocuo decoction)and a treatment group(treated with self-made Chushi Xiaocuo decoction combined with fire needle bloodletting).The symptoms and skin lesion scores,fungal examination,adverse reactions,and other indicators were recorded before and after treatment in both groups.Results After treatment,the marked effective rate of the treatment group was 88.89%,while the marked effective rate of the control group was 65.38%,with a significant difference between them(P<0.05).The self-conscious symptoms were significantly improved in the two groups(P<0.01),and there was a significant difference between the two groups(P<0.01).There was a significant difference in fungal clearance rate between the two groups(P<0.05).There were no significant local skin reactions or other possible adverse reactions in the two groups(P>0.05).Conclusion The combination of fire needle bloodletting and Chushi Xiaocuo decoction is effective in the treatment of Malassezia folliculitis,which can inhibit fungal infection,with no significant adverse reactions and a high safety.Its mechanism may be related to a decrease in local skin inflammation and an improvement in microcirculation.