背景:如何有效地将碳纳米管均匀分散于支架之中,是构建理想碳纳米管化支架的关键环节之一,也是目前研究的热点之一.目的:综述构建含均一稳定分布碳纳米管的心肌组织工程支架的方法学进展.方法:由第一作者检索Web of Science Core Collection数据库、PubMed数据库2004年10月至2017年1月的相关文献,英文关键词为"carbon nanotubes, dispersion,cardiac tissue engineering",检索文献类型为研究原著,通过标题、摘要内容及正文内容筛选文献进行综述.结果与结论:高比表面积、高深宽比和表面高低不平会导致碳纳米管聚集成束,因此能否将碳纳米管在聚合物支架中均匀稳定地分散开来,是构建理想的碳纳米管/聚合物复合支架的关键之一.在心肌组织工程中,对碳纳米管表面进行化学操作(共价修饰)或物理操作(非共价修饰),可显著改善其分布的均一性和稳定性,有助于制备含均一稳定分散碳纳米管的心肌组织工程支架,明显改善工程心肌的机械性能和电传导性能.
BACKGROUND: How to efficiently and uniformly disperse carbon nanotubes (CNTs) into a tissue-engineered scaffold is crucial to construct an ideal CNTs-Polymer composite scaffold and it is also a hotspot of research in the tissue engineering. OBJECTIVE: To review the advances in the methodology progress of constructing a scaffold for cardiac tissue engineering, which contains uniformly and stably dispersed CNTs. METHODS: The Web of Science Core Collection and PubMed were searched by the first author for related papers about CNTs dispersion in the cardiac tissue engineering published from October 2004 to January 2017. The key words were "carbon nanotubes, dispersion, cardiac tissue engineering" in English. Original research papers were searched, which were screened through titles, abstracts and contents, and then reviewed. RESULTS AND CONCLUSION: CNTs are easy to aggregate because of high surface area, high aspect ratio and rough surface. Thus, it is one of the key points to construct an ideal CNTs-Polymer composite scaffold that whether CNTs could be uniformly and stably dispersed in polymer scaffolds. In the cardiac tissue engineering, covalent or non-covalent surface modification of CNTs significantly enhances the uniformity and stability of CNTs in the polymer scaffolds, which is conducive to construct the uniformly and stably CNTs-dispersed scaffold for cardiac tissue engineering, leading to notable improvement in mechanical and electrical properties of engineered cardiac tissues.