目的 观察珍珠烫伤膏保留灌肠治疗慢性非特异性溃疡性结肠炎的临床疗效.方法 将76例慢性非特异性溃疡性结肠炎患者随机分为2组.治疗组40例予珍珠烫伤膏保留灌肠治疗,对照组36例予锡类散保留灌肠治疗.2组均治疗14 d统计临床疗效,并观察2组治疗前后主要症状、体征积分及结肠镜下黏膜病变积分变化.结果 治疗组总有效率95.0%,对照组总有效率83.3%,2组比较差异有统计学意义(P<0.05),治疗组疗效优于对照组.2组治疗后脓血便、腹痛、腹泻、腹胀、肛门灼热、里急后重症状积分均降低(P<0.05),且治疗组积分降低优于对照组(P<0.05).2组治疗后结肠镜下黏膜病变充血、水肿、糜烂、溃疡积分均降低(P<0.05),且治疗组积分降低优于对照组(P<0.05).结论 珍珠烫伤膏保留灌肠治疗慢性非特异性溃疡性结肠炎疗效确切,且能改善患者的临床症状,促进肠道黏膜病变部位的组织修复.
Objective To observe the clinical effect of Pearl Scald Ointment retention enema on the treatment of chronic nonspecific ulcerative colitis (CUC).Methods 70 subjects with CUC were randomly divided into two groups.40 subjects in treatment group were treated by Pearl Scald Ointment retention enema.36 subjects in control group were treated by Xilei powder retention enema.The curative effect was evaluated 14 d after treatment in two groups.The indexes of main symptoms,sings and mucosal lesions of colonoscopy after treatment were observed in two groups.Results The total effective rate in treatment and control group was 95.0% and 83.3% respectively with statistical difference (P < 0.05).The integrals of bloody purulent stool,stomachache,diarrhea,abdominal distention,the scorch of anus and tenesmus after treatment were decreased in two groups (P < 0.05),and the decrease in treatment group was superior to that in control group (P < 0.05).The integrals of mucosal lesions of colonoscopy including congestion,edema,erosion and ulcer area after treatment were decreased in two groups (P < 0.05),and the decrease in treatment group was superior to that in control group (P < 0.05).Conclusion Pearl Scald Ointment retention enema has exact effect on the treatment of CUC,can improve the clinical symptoms,and promote lesion tissue of intestinal mucosa repair.