目的 探讨中性粒细胞/淋巴细胞比值(NLR)与白塞病(BD)疾病活动性的相关性.方法 103例BD患者依据电子病历疾病活动性指数(EMRAI)评分分为低活动性组(0~4分,61例)和高活动性组(5~11分,42例).检测患者白细胞计数(WBC)、中性粒细胞计数(NEU)、淋巴细胞计数(LY)、血小板计数(PLT)、红细胞计数(RBC)、血红蛋白(Hb)、红细胞沉降率(ESR)、C反应蛋白(CRP)、IgG、IgA、IgM及补体C3、C4,计算NLR和血小板/淋巴细胞比值(PLR);分析NLR、PLR与全体患者ESR、CRP、EMRAI的相关性;采用Logistic回归分析BD疾病活动性的影响因素;绘制受试者工作特征(ROC)曲线,评估NLR对BD疾病活动性的判断效能.结果 高活动性组患者WBC、NEU、PLT、ESR、CRP、NLR、PLR及补体C3、C4均高于低活动性组(P<0.05),余指标差异均无统计学意义(P>0.05).NLR与全体患者ESR、CRP、EMRAI呈正相关,PLR与全体患者ESR、CRP、EMRAI呈正相关(P<0.05).Logistic回归分析显示,高NLR是BD疾病活动性的危险因素(OR=1.511,95%CI:1.080~2.113,P<0.05).ROC曲线分析结果显示,NLR评估BD疾病活动性的曲线下面积(AUC)为0.706(95%CI:0.603~0.809).结论 NLR对BD患者疾病活动性有一定的判断效能,可作为BD疾病活动性评估的生物学指标.
Objective To explore the correlation between neutrophil-to-lymphocyte ratio(NLR)and Behcet's disease(BD)activity.Methods A total of 103 BD patients were divided into the low activity group(0-4,61 cases)and the high activity group(5-11,42 cases)according to electronic medical record-based disease activity index(EMRAI)score.The white blood cell(WBC),neutrophil(NEU),lymphocyte(LY),platelet(PLT),red blood cell(RBC),hemoglobin(Hb),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),IgG,IgA,IgM,complement C3 and C4 were detected.NLR and platelet-to-lymphocyte ratio(PLR)were calculated.The correlation between NLR,PLR and ESR,CRP,EMRAI were analyzed.Logistic regression was used to analyze the influencing factors of BD disease activity.Receiver operating characteristic(ROC)curve was drawn to evaluate the effectiveness of NLR in judging BD disease activity.Results WBC,NEU,PLT,ESR,CRP,NLR,PLR,complement C3 and C4 in patients were higher in the high activity group than those in the low activity group(P<0.05),and there were no significant differences in other indexes(P>0.05).NLR was positively correlated with ESR,CRP and EMRAI in the whole group,while PLR was positively correlated with ESR,CRP and EMRAI in the whole group(P<0.05).Logistic regression analysis showed that high NLR was a risk factor for BD disease activity(OR=1.511,95%CI:1.080-2.113,P<0.05).ROC curve analysis showed that the area under the curve(AUC)of NLR in evaluating BD disease activity was 0.706(95%CI:0.603-0.809).Conclusion NLR is effective in judging the disease activity of BD patients,and can be used as a biological index to evaluate the disease activity of BD.