非酒精性脂肪性肝病(NAFLD)是指除酒精和其他明确损肝因素外导致的、与胰岛素抵抗密切相关的代谢应激性肝损伤,主要特征为肝细胞内脂肪过度沉积.NAFLD发病机制复杂,目前尚无正式获批的治疗药物.传统中药资源丰富,在治疗慢性肝病上具有独特的优势,发展前景广阔.近年来,一些中药多糖被广泛应用于防治NAFLD.文章对中药多糖防治NAFLD的研究进展进行综述,以期为中药多糖在兽医临床中防治NAFLD方面的应用及后续研究提供参考.
NAFLD refers to the metabolic stress liver injury caused by alcohol and other specific liver damage factors,which is closely related to insulin resistance,and is mainly characterized by excessive fat deposition in liver cells.The pathogenesis of NAFLD is complex,and there are no officially approved drugs to treat it.Traditional Chinese medicine boasts abundant resources and possesses unique advantages in the treatment of chronic liver diseases,with broad prospects for development.In recent years,some traditional Chinese medicine polysaccharides have been widely used in the prevention and treatment of NAFLD.The article reviews the research progress of traditional Chinese medicine polysaccharides in the prevention and treatment of NAFLD,in order to provide a reference for the application of traditional Chinese medicine polysaccharides in the prevention and treatment of NAFLD in veterinary clinic and follow-up research.