帕金森病(PD)是一种常见于老年人的神经系统变性疾病,主要以静止性震颤、运动迟缓、肌肉强直为主要特征.秀丽隐杆线虫在神经系统疾病研究方面具有其独特优势,是一种广泛应用的模式生物.该文简要归纳了秀丽隐杆线虫模型的特点,重点综述了秀丽隐杆线虫在PD研究中的应用,为PD机制研究及新药研发提供了参考和选择.
Parkinson's disease(PD)is a neurodegenerative disease commonly in the elderly,which is mainly characterized by resting tremor,bradykinesia,and muscle tonus.Caenorhabditis elegans has its unique advantages in the study of neurological diseases and is a widely used model organism.The paper briefly sum-marized the characteristics of the Caenorhabditis elegans model and focuses on the application of Caenorhabdi-tis elegans in the study of PD,which provided reference and options for the study of PD mechanism and the development of new drugs.