流行病学证据表明口腔是人乳头瘤病毒(human papillomaviruses,HPV)的储存库,水平传播和垂直传播等多种途径促进了口腔HPV感染的流行.低危型HPV感染可能导致口腔黏膜良性病变,而高危型HPV的持续感染是诱发头颈部鳞状细胞癌的重要危险因素.目前,我国关于口腔HPV感染的研究工作并不深入,国人对相关知识的认知不足,这不利于相关疾病防治工作的开展.在此背景下,本文对口腔HPV感染的研究现状进行综述,以期为我国口腔HPV感染的防治工作提供参考.
Epidemiologic evidences have demonstrated that the oral cavity is a reservoir for human papillomavirus(HPV).Multiple transmission routes including horizontal transmission and vertical transmission increase the incidence of oral HPV infection.Low-risk HPV may cause benign lesions of the oral mucosal,and persistent infection with high-risk HPV is an important risk factor for the devel-opment of head and neck squamous cell carcinoma.At present,the research on oral HPV infection in China is not in-depth,and Chi-nese people have insufficient understanding of relevant knowledge,which is not conducive to the development of related disease preven-tion and treatment.In this context,this article reviews the current research status of oral HPV infection,in order to provide reference for the prevention and treatment of oral HPV infection in China.