目前,速溶药物传递系统研究的主要内容包括口腔崩解片和口腔速溶膜,它们无需水或咀嚼便能在1 min内快速崩解,因而改善了患者的依从性.近年来,许多新型速溶技术的出现,进一步推动了速溶药物传递系统的发展.本文介绍了几种新型速溶技术,如冷冻干燥技术、3D打印技术和预混崩解剂在制备口腔崩解片,以及静电纺丝技术、热熔挤出技术、喷墨打印和柔性打印在制备口腔速溶膜中的应用,并简要总结了上述新型速溶技术的优缺点.
At present,orally disintegrating tablets and fast dissolving oral films are the main research directions of fast dissolving drug delivery system (FDDDS),which can dissolve or disintegrate within a minute without drinking water or mastication so as to improve patient compliance.In recent years,many novel fast-dissolving technologies have promoted the development of FDDDS.This review introduces some applications of several noval fast-dissolving technologies to preparation of orally disintegrating tablets and fast dissolving oral films,such as freeze-dried thchnology,three-dimensional printing,co-processed disintegrants,electrospinning,hot melt extrusion,ink-jet printing and flexographic priming technology.Their advantages and disadvantages are brifely introduced as well.