目的::确定抑郁焦虑情绪对 CA 复发和细胞免疫的影响。方法:采用抑郁自评量表( SDS)和焦虑自评量表( SAS)对100例初诊CA进行问卷调查,评估其情绪状态。 SDS>50和/或SAS>50为抑郁焦虑者,其余患者为非抑郁焦虑者。选择健康体检32人为对照。流式细胞技术测定外周血Treg细胞水平。随后观察两组CA治疗后的复发率。结果: CA组外周血 Treg细胞水平为(8.03±2.14)%,显著高于正常对照组(5.28±1.21)%(P<0.05);抑郁焦虑组外周血Treg细胞水平为(8.64±2.12)%,显著高于无抑郁焦虑组(7.55±2.05)%(P<0.05)。治疗后抑郁焦虑组第1、2、3、6个月的复发率均高于无抑郁焦虑组。结论:抑郁和/或焦虑情绪可加剧CA患者细胞免疫功能的抑制,导致CA更易复发。
Objective:To determine the impact of depression and anxiety on the immunological status and recurrence in the patients with condyloma acuminatum ( CA) . Methods: The emotional state of 100 CA pa-tients was evaluated with Self-rating Depression Scale ( SDS) and Self-rating Anxiety Scale ( SAS) . If SDS>50 and/or SAS>50, the patient was judged as having depression and anxiety, otherwise, as having no depres-sion and anxiety. The level of peripheral blood regulatory T cells were assayed by flow cytometry. Results:The level of peripheral blood regulatory T cells was significantly higher in CA patients (8.64±2.12)% than in the normal control group (5.28±1.21)%. The level of peripheral blood regulatory T cells among the patients with depression and anxiety (8.64±2.12)% was significantly higher than that among the patients without depression and anxiety (7.55±2.05)%. The recurrence rate of CA after treatment was higher in the patients with depres-sion and anxiety than in the patients without depression and anxiety at month 1, 2, 3 and 6. Conclusion:De-pression and anxiety may increase inhibition of cellular immune function in CA patients, resulting in higher likelihood for CA relapse.