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요약정보
高脂血症人群预测潜在冠心病风险模型的临床研究
Resource Type
Academic Journal
Authors
刘少凯
;
张彦伟
;
王春晖
;
刘小霞
;
刘彦宏
;
孙一恺
;
张彦清
Source
中西医结合心脑血管病杂志 / Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular Disease
. 21(5):885-888
Subject
高脂血症
冠心病
单核苷酸多态性
预测模型
Language
Chinese
ISSN
1672-1349
Online Access
Find it @ DONGA
초록
目的:通过建立包含基因水平的高脂血症潜在冠心病风险预测模型,使血脂异常人群能够预测潜在冠心病风险,从而降低出现潜在心血管事件的风险.方法:采用病例对照研究,选取山西医科大学第一医院收治的576例高脂血症病人,根据是否确诊为冠心病分为冠心病组与对照组.采用MassARRAY遗传分析系统进行SNP基因分型,应用二元Logistic回归分析建立预测模型.结果:rs216172与rs7136259位点与冠心病风险密切相关,可以作为高脂血症人群出现冠心病风险的易感基因,其中rs216172位点的G等位基因是冠心病发病的危险因素,G等位基因较C等位基因患冠心病的概率高出2.953倍(P=0.013),而对rs7136259位点分析中,认为T等位基因相对于C等位基因具有更高的危险度,其TT基因型相对于CC基因型患冠心病的风险提高了1.908倍(P=0.043).结论:建立了包含rs216172、rs7136259以及性别、年龄、糖尿病等冠心病风险因素的预测模型,希望能够预测高脂血症人群潜在冠心病风险.
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