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요약정보
自拟滋阴清火饮治疗复发性阿弗他溃疡的疗效观察及其对唾液EGF、血清TNF-α水平的影响
Resource Type
Academic Journal
Authors
吴峥婧
;
陈夷钒
Source
中国中医药科技 / Chinese Journal of Traditional Medical Science and Technology
. 29(5):802-804
Subject
复发生阿弗他溃疡
滋阴清火饮
疼痛
唾液EGF
血清TNF-α
Language
Chinese
ISSN
1005-7072
Online Access
Find it @ DONGA
초록
目的:观察自拟滋阴清火饮治疗复发性阿弗他溃疡(RAU)的疗效并探讨其对唾液表皮生长因子(EGF)、血清肿瘤坏死因子-α(TNF-α)的影响.方法:160例RAU患者,随机分为2组,每组80例.对照组患者给予西地碘含片、维生素B2片、维生素C片治疗;观察组给予口服自拟滋阴清火饮治疗,连续治疗5 d.比较2组治疗后疗效;比较2组患者溃疡愈合时间及复发率;比较2组患者治疗前后溃疡疼痛评分及唾液EGF、血清TNF-α水平变化.结果:经治疗后,观察组总有效率(97.5%)高于对照组(80.0%)(P<0.05);治疗后2组患者溃疡疼痛评分均显著下降,且观察组下降更为显著(P<0.05);治疗后2组患者唾液EGF、血清TNF-α均明显改善,且观察组改善尤其明显(P<0.05);观察组患者溃疡愈合时间明显短于对照组(P<0.05);随访半年,观察组复发率(5.0%)低于对照组(30.0%)(P<0.05).结论:滋阴清火饮治疗RAU疗效良好,可调节机体内唾液EGF、血清TNF-α水平,能明显减轻患者溃疡导致的疼痛及缩短溃疡愈合的时间,减少复发.
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