目的 探讨脑卒中患者白质高信号体积变化与认知功能的相关性.方法 2020年7月-2021年1月139例脑卒中患者为研究对象,采用蒙特利尔认知评估量表(MoCA)及MRI评估患者基线认知功能及白质高信号体积,随访1年后,再次收集患者认知功能情况及白质高信号体积,分析脑卒中患者白质高信号体积变化情况及认知功能情况,并根据患者认知功能情况分为正常组和障碍组,探讨白质高信号体积变化与患者认知功能降低的相关性.结果 139例患者随访1年后,共9例失访,最终纳入130例脑卒中患者,46.15%(60/130)的脑卒中患者白质高信号体积进展,23.85%(31/130)患者白质高信号体积改善,30.00%(39/130)白质高信号体积保持稳定.其中53例患者出现认知功能障碍为障碍组,77例为认知功能正常组.两组患者年龄、性别等一般资料比较差异无统计学意义(P>0.05),白质高信号体积变化障碍组高于正常组(P<0.05),Pearson相关性分析显示,脑卒中患者白质高信号体积变化与患者认知功能评分呈负相关(P<0.05).结论 脑卒中后患者白质高信号体积变化多呈进展趋势,并与患者认知功能评分呈负相关.
Objective To investigate the changes of white matter hyperintensity volume and its correlation with cognitive function in stroke patients.Methods A total of 139 stroke patients in our hospital from July 2020 to January 2021 were included as the research objects.Montreal Cognitive Assessment(MoCA)and magnetic resonance imaging(MRI)were used to evaluate the patients.Baseline cognitive function and white matter hyperintensity volume were followed up for 1 year.The cognitive function and white matter hyperintensity volume of patients were collected again,and the changes in white matter hyperintensity volume and cognitive function in stroke patients were analyzed.The patients were divided into a normal group and a disabled group to explore the correlation between the volume change of white matter hyperintensity and the decrease of cognitive function in patients.Results After 1 year follow-up of 139 patients,a total of 9 patients were lost to follow-up.Finally,130 stroke patients were included.46.15%(60/130)of stroke patients progressed in white matter hyperintensity volume,23.85%(31/130)of patients with white matter.The hyperintensity volume regressed,and 30.00%(39/130)of the white matter hyperintensity volume remained stable.Among them,53 patients with cognitive dysfunction were in the impaired group and 77 were in the normal group.There was no statistical difference in general data such as age and gender between the two groups(P>0.05).The white matter hyperintensity volume change disorder group was higher than the normal group(P<0.05).The change of signal volume was negatively correlated with the patient's cognitive function score(P<0.05).Conclusion The changes of white matter hyperintensity volume in post-stroke patients tend to be progressive and negatively correlated with cognitive function scores.