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요약정보
宫腔粘连大鼠模型研究进展 / Research Progress in Rat Models of Intrauterine Adhesion
Resource Type
Academic Journal
Authors
黄少凤
;
林忠
;
朱雪红
;
刘姝岑
;
宾力
;
HUANG Shaofeng
;
LIN Zhong
;
ZHU Xuehong
;
LIU Shucen
;
BIN Li
Source
实验动物与比较医学 / Laboratory Animal and Comparative Medicine
. 42(6):560-565
Subject
宫腔粘连
动物模型
大鼠
Language
Chinese
ISSN
1674-5817
Online Access
Find it @ DONGA
초록
完整的内膜及适当的内膜厚度是子宫生殖功能正常的必要条件.宫腔粘连(intrauterine adhesion,IUA)可致患者反复流产及不孕等,严重影响患者的正常生育功能.目前,对于IUA的治疗方式有手术消除、使用雌激素等,但存在治疗效率较低、易复发、妊娠率仍然较低等问题.IUA发生、发展的具体机制及子宫内膜受损后的修复机制尚不明晰,建立合适的动物模型有助于开展人类IUA各方面的研究.本文介绍了近些年IUA大鼠模型的造模方法,包括物理机械损伤法、化学法、生物损伤法、联合损伤法,然后从模型成模率、稳定性、IUA发病机制等方面阐述其适用情况,并探讨评价建模成功与否的观察指标,以期为从事相关领域研究的专业人员选择合适的造模方法提供有益的参考.总的来说,妊娠大鼠的反复内膜受损与感染联合模型或许能更贴合临床多次流产、刮宫术后合并感染引起的IUA.
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