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요약정보
壳聚糖微球分散体系的抑菌性研究 / Antibacterial Activities of Chitosan Microspheres
Resource Type
Academic Journal
Authors
任丽宏
;
陈西广
;
程晓杰
;
周旋
;
孔明
;
REN Li-hong
;
CHEN Xi-guang
;
CHENG Xiao-jie
;
ZHOU Xuan
;
KONG Ming
Source
天然产物研究与开发 / Natural Product Research and Development
. 23(5):828-832
Subject
壳聚糖微球
乳化交联法
抑菌活性
Language
Chinese
ISSN
1001-6880
Online Access
Find it @ DONGA
초록
以乳化交联法制备的壳聚糖微米微球(CMs)为试验材料,研究其对金黄色葡萄球菌和大肠杆菌的抑菌行为,并对其浓度因素、粒径因素和抑菌机理做了探讨.结果表明CMs的抑菌作用随其浓度的增加和粒径的减小而增强.在浓度<0.7 mg/mL时,CMs对细菌的生长具有先抑制后促进的作用;当浓度≥0.7 mg/mL时对细菌有杀灭作用.CMs对两种细菌的最小抑菌浓度和最小杀菌浓度分别为0.8、1.4 mg/mL和1.0、1.8 mg/mL,表明壳聚糖微球对金黄色葡萄球菌和大肠杆菌均具有明显的抑制作用,且金黄色葡萄球菌对微球抑制作用的反应比大肠杆菌更敏感.扫描电子显微镜观察发现,细菌能迅速贴附在CMs表面,并且贴壁后的细菌发生了明显的形态变化,有的甚至完全被破坏.
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