目的 探究加味半夏泻心汤联合西药治疗在脾胃湿热型幽门螺杆菌(HP)阳性慢性胃炎患者中的应用效果.方法 选取新余市中医院 2020 年 1 月至 2022 年 8 月收治的 118 例脾胃湿热型HP阳性慢性胃炎患者,按照随机数字表法分为两组,各 59 例.对照组采用西药四联疗法治疗,在上述基础上,观察组加服加味半夏泻心汤.对比两组临床疗效、中医证候积分、HP清除率、HP复发率、不良反应.结果 观察组治疗总有效率高于对照组(P<0.05).治疗后,观察组中医证候积分低于对照组(P<0.05);HP清除率高于对照组;随访半年HP复发率低于对照组(P<0.05).两组不良反应对比,差异无统计学意义(P<0.05).结论 脾胃湿热型HP阳性慢性胃炎患者采用加味半夏泻心汤联合西药治疗,效果显著,利于改善中医证候积分,提升HP清除率,降低复发率,且临床应用安全性较高.
Objective To explore the effect of modified banxia xiexin decoction combined with western medicine in the treatment of patients with helicobacter pylori(HP)positive gastritis in spleen and stomach dampness-heat type.Methods 118 cases of HP positive chronic gastritis with dampness-heat in spleen and stomach admitted to Xinyu Hospital of Traditional Chinese Medicine,from January 2020 to August 2022 were divided into two groups according to random number table method,with 59 cases in each group.The control group was treated with quadruple therapy,on the basis of the above,the observation group was given modified banxia xiexin decoction.The clinical efficacy,TCM syndrome score,HP clearance rate,HP recurrence rate and adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group(P<0.05).The TCM syndrome score of the observation group was lower than that of the control group(P<0.05),the HP clearance rate of observation group was higher than that of control group after treatment,and the HP recurrence rate of half a year follow-up was lower than that of control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The combination of modified banxia xiexin decoction with western medicine in the treatment of HP positive chronic gastritis with dampness-heat in the spleen and stomach has a significant effect,which is conducive to improving the TCM syndrome score,increasing the HP clearance rate,reducing the recurrence rate,and has high clinical safety.