We provide novel constraints on the parameters defining the universal pressure profile (UPP) within clusters of galaxies, and explore their dependence on the cluster mass and redshift, from measurements of Sunyaev-Zel'dovich Compton-$y$ profiles. We employ both the $\textit{Planck}$ 2015 MILCA and the ACT-DR4 $y$ maps over the common $\sim 2,100\,\text{deg}^2$ footprint. We combine existing cluster catalogs based on KiDS, SDSS and DESI observations, for a total of 23,820 clusters spanning the mass range $10^{14.0}\,\text{M}_{\odot}Comment: 39 pages, 22 figures. Accepted for publication in ApjS