We pursue a uniform quantization of all twists of 4-dimensional N = 4 supersymmetric Yang-Mills theory, using the BV formalism, and we explore consequences for factorization algebras of observables. Our central result is the construction of a one-loop exact quantization on $\mathbb R^4$ for all such twists and for every point in a moduli of vacua. When an action of the group SO(4) can be defined - for instance, for Kapustin and Witten's family of twists - the associated framing anomaly vanishes. It follows that the local observables in such theories can be canonically described by a family of framed $\mathbb E_4$ algebras; this structure allows one to take the factorization homology of observables on any oriented 4-manifold. In this way, each Kapustin-Witten theory yields a fully extended, oriented 4-dimensional topological field theory \`a la Lurie and Scheimbauer.
Comment: 54 pages, 3 figures. Comments welcome!