Study of the tools available in biological dosimetry to estimate the dose in cases of accidental complex overexposure to ionizing radiation: The Lilo accident
- Resource Type
- Authors
- V. Durand; Laurence Roy; M. Delbos; Eric Gregoire; Patrick Gourmelon; Valérie Buard; P. Voisin; I. Sorokine-Durm; N. Paillole
- Source
- International Journal of Radiation Biology
International Journal of Radiation Biology, 2006, 82 (1), pp.39-48. ⟨10.1080/09553000600579207⟩
- Subject
- Ionizing
radiation accident
[SDV]Life Sciences [q-bio]
radiation exposure
dose calculation
Translocation, Genetic
cytogenetics
030218 nuclear medicine & medical imaging
Ionizing radiation
0302 clinical medicine
Russian Federation
Radiation, Ionizing
Dose estimation
Medicine
army
Radiation
Radiological and Ultrasound Technology
dosimetry
article
chromosome analysis
priority journal
030220 oncology & carcinogenesis
Radiological weapon
blood sampling
Radioactive Hazard Release
ionizing radiation
radiation dose
radiation monitoring
Translocation
03 medical and health sciences
Genetic
cesium
Dosimetry
follow up
Humans
Radiology, Nuclear Medicine and imaging
controlled study
human
intermethod comparison
Radiometry
Chromosome Aberrations
business.industry
human cell
scoring system
dicentric chromosome
radiobiology
Accidental
Accidents
business
Nuclear medicine
chromosome translocation
mathematical model
- Language
- English
Purpose: To compare the efficiency of different cytogenetic tools in estimating the doses received by four people involved in the Lilo accident and to monitor the dose estimate over 4.5 years. Materials and methods: Several young Georgian frontier guards handled at least one of the 12 Caesium sources found in a former Russian military camp. Overexposure lasted from July 1996 to May 1997. The Institute for Radiological Protection and Nuclear Safety (IRSN) obtained blood samples taken at several intervals post-exposure from the four most highly-exposed people. Dose estimation was performed using dicentric and translocation scoring. Results: The first dose estimations performed by dicentric scoring gave whole-body doses ranging from 0.4 to 1.3 Gy. Overexposure was complex and several mathematical models were used to take this complexity into account. This could provide information concerning the circumstances of overexposure. Concerning follow-up, the yield of dicentrics decreased by about 50% in the first 4 months following the end of overexposure whereas translocations were stable over the period of analysis. Conclusion: It has been useful to compare cytogenetic results with clinical results. The results presented here reveal good stability of translocations. However the first dose estimation was not attempted until 6 months after the last exposure. © 2006 Taylor & Francis.