All children undergo needle procedures as part of routine medical care. Numerous interventions are available for relieving pain from needle procedures. These interventions can be divided into four domains (4 Ps of pain management): Procedural, pharmacological, psychological, and physical. Treating needle pain reduces pain and distress and improves satisfaction with medical care. Other potential benefits include a reduction in the development of needle fear and subsequent healthcare avoidance behavior. Adoption of the 4 Ps into routine clinical practice is feasible and should become a standard of care in the delivery of health care for children. There are various effective approaches for translating the research evidence into practice that target different stakeholders involved in children’s health care, including children, parents, health providers, and educators. This chapter is a narrative review of the current knowledge about epidemiology, pain experience, practices and attitudes, evidence-based interventions, and knowledge translation for pain management during common needle procedures.