PVA engineered microcapsules for targeted delivery of camptothecin to HeLa cells
- Resource Type
- Authors
- Simone Beninati; Blasco Morozzo della Rocca; Alessandro Desideri; Claudio Tabolacci; Alice Galbiati; Gaio Paradossi
- Source
- Subject
- Vinyl alcohol
Materials science
CAMPTOTHECIN
Bioadhesive
Bioengineering
Nanotechnology
macromolecular substances
engineering.material
Biomaterials
Chitosan
HeLa
chemistry.chemical_compound
Coating
medicine
biology
Settore BIO/11
drug targeting
biology.organism_classification
chemistry
Mechanics of Materials
PVA
engineering
Microbubbles
Nanomedicine
Camptothecin
medicine.drug
- Language
- English
Capsular microvectors are an important tool in the recent research field of nanomedicine to address a drug cargo for the therapeutic treatment of several pathologies. In this study we describe how the product of the conjugation of the polysaccharide chitosan with folate can be used as a coating of poly (vinyl alcohol), PVA, based microcapsules for an efficient targeting of HeLa cells. The influence of the coating on the bioadhesive properties of the vector and on its cargo capacity was also considered using camptothecin as an anticancer drug model. The coating strategy was finalized to exploit the good chemical versatility of PVA, used to form the shell of the vector. This study is a follow up of an investigation activity aiming to show the potentialities of PVA-shelled microcapsules or microbubbles as injectable microdevices supporting a theranostic approach for different types of tumour.