Exercise improves recognition memory and synaptic plasticity in the prefrontal cortex for rats modelling vascular dementia
- Resource Type
- Authors
- Jingpu Zhao; Yangyang Lin; Huiying Liang; Xiaokuo He; Xiuyuan Zheng; Minghong Sui; Tiebin Yan; Zhiqiang Zhuang; Juntao Dong
- Source
- Neurological Research. 40:68-77
- Subject
- Male
0301 basic medicine
Prefrontal Cortex
Nerve Tissue Proteins
03 medical and health sciences
0302 clinical medicine
Physical Conditioning, Animal
Neuroplasticity
medicine
Animals
Functional electrical stimulation
Rats, Wistar
Vascular dementia
Prefrontal cortex
Recognition memory
Regulation of gene expression
Memory Disorders
Neuronal Plasticity
business.industry
Dementia, Vascular
Membrane Proteins
Recognition, Psychology
General Medicine
medicine.disease
Rats
Disease Models, Animal
030104 developmental biology
Gene Expression Regulation
Neurology
Membrane protein
Synaptic plasticity
Exploratory Behavior
Neurology (clinical)
business
Neuroscience
030217 neurology & neurosurgery
- Language
- ISSN
- 1743-1328
0161-6412
Functional electrical stimulation (FES) may induce involuntary exercise and make beneficial effects on vascular dementia (VD) by strengthening the BDNF-pCREB-mediated pathway and hippocampal plasticity. Whether FES improves recognition memory and synaptic plasticity in the prefrontal cortex (PFC) was investigated by establishing a VD model.The VD rats were administered with two weeks of voluntary exercise, forced exercise, or involuntary exercise induced with FES. Sham-operated and control groups were also included. The behavioral changes were assessed with the novel object recognition test and novel object location test. The expression levels of key proteins related to synaptic plasticity in the PFC were also detected.All types of exercise improved the rats' novel object recognition index, but only voluntary exercise and involuntary exercise induced with FES improved the novel object location index. Any sort of exercise enhanced the expression of key proteins in the PFC.Involuntary exercise induced with FES can improve recognition memory in VD better than forced exercise. The mechanism is associated with increased synaptic plasticity in the PFC. FES may be a useful alternative tool for cognitive rehabilitation.