Integration of low muscle mass into the IPS system and its prognostic significance in patients with Hodgkin's lymphoma
- Resource Type
- Authors
- Anil Tombak; Mehmet Ali Ucar; Cagatay Cavusoglu; Eyup Naci Tiftik; Erkan Guler; Mahmut Bakır Koyuncu; Aydan Akdeniz; Tolga Koseci
- Source
- Biomarkers in medicine. 16(2)
- Subject
- Oncology
medicine.medical_specialty
Clinical Biochemistry
Increased AUC
Vinblastine
Prognostic score
Low muscle mass
Bleomycin
Internal medicine
Positron Emission Tomography Computed Tomography
Drug Discovery
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
In patient
Neoplasm Staging
Receiver operating characteristic
business.industry
Muscles
Biochemistry (medical)
medicine.disease
Hodgkin's lymphoma
Prognosis
Hodgkin Disease
Dacarbazine
ABVD
Doxorubicin
Sarcopenia
business
medicine.drug
- Language
- ISSN
- 1752-0371
Aim: The aim of this study is to determine whether a novel prognostic score can be obtained by including low muscle mass in the international prognostic score (IPS) system. Materials & Methods: Psoas muscle areas were determined in the PET/CT scans of the patients taken for staging at the time of diagnosis and after two cycles of ABVD. After evaluating the effect of low muscle mass on overall survival, receiver operating characteristic (ROC) analyzes were performed by including it in IPS systems. Results: Overall survival was significantly lower in patients with low muscle mass. Adding low muscle mass to IPS scores increased AUC, sensitivity and specificity. Conclusion: The integration of low muscle mass into the IPS scoring systems increased the success of these systems in predicting a prognosis.