Enantioselective C–S bond formation by iron/Pybox catalyzed Michael addition of thiols to (E)-3-crotonoyloxazolidin-2-one
- Resource Type
- Authors
- Motoi Kawatsura; Masashi Yamamoto; Toshiyuki Itoh; Yuji Komatsu; Shuichi Hayase
- Source
- Tetrahedron Letters. 48:6480-6482
- Subject
- Chemistry
Organic Chemistry
Drug Discovery
Enantioselective synthesis
Michael reaction
Organic chemistry
Bond formation
Biochemistry
Iron catalyst
Catalysis
- Language
- ISSN
- 0040-4039
The enantioselective Michael addition of thiols to (E)-3-crotonoyloxazolidin-2-one was effectively catalyzed by the Fe(BF4)2·6H2O/(S,S)-ip-Pybox catalyst, and the addition product was obtained with up to a 95% ee.