This paper proposes a data-driven terminal sliding mode decoupling controller with prescribed performance for a class of discrete-time multi-input multi-output systems in the presence of external disturbances and uncertainties. First, utilizing a discrete-time extended state observer and a compact form dynamic linearization data model, we derive a new data-driven mothod and establish the relationship between the input and output signals of controlled plant. Moreover, the disturbances, uncertainties, and couplings are suppressed owing to the application of the terminal sliding mode technique. Combined with the principle of prescribed performance control, the terminal sliding mode law with prescribed performance is derived. With the proposed data-driven method, the tracking error is lower, and the decoupling ability is improved. Furthermore, the stability of the control system is proven. Finally, a simulation is conducted on a three-tank system to demonstrate the effectiveness of the proposed scheme.