Cell-Based Therapy in Allergy
- Resource Type
- Authors
- Martina Gattringer; Thomas Wekerle; Ulrike Baranyi; Rudolf Valenta
- Source
- Vaccines against Allergies ISBN: 9783642200533
- Subject
- Allergy
Adoptive cell transfer
business.industry
medicine.medical_treatment
Hematopoietic stem cell transplantation
medicine.disease
Immune tolerance
Transplantation
Graft-versus-host disease
Antigen
Immunology
medicine
Stem cell
business
- Language
IgE-mediated allergy is an immunological disorder occurring in response to otherwise harmless environmental antigens (i.e., allergens). Development of effective therapeutic or preventive approaches inducing robust tolerance toward allergens remains an unmet goal. Several experimental tolerance approaches have been described. The therapeutic use of regulatory T cells (Tregs) and the establishment of molecular chimerism are two cell-based strategies that are of particular interest. Treg therapy is close to clinical application, but its efficacy remains to be fully defined. Recent proof-of-concept studies demonstrated that transplantation of syngeneic hematopoietic stem cells modified in vitro to express a major allergen leads to molecular chimerism and robust allergen-specific tolerance. Here we review cell-based tolerance strategies in allergy, discussing their potentials and limitations.