Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease
- Resource Type
- Authors
- Tomiichiro Oda; Caleb E. Finch; Philippe Bertrand; Giulio Maria Pasinetti; Judes Poirier
- Source
- Brain research. Molecular brain research. 33(1)
- Subject
- Apolipoprotein E
medicine.medical_specialty
Genotype
Hippocampus
Nerve Tissue Proteins
Biology
Cellular and Molecular Neuroscience
Degenerative disease
Apolipoproteins E
Alzheimer Disease
Internal medicine
medicine
Humans
Molecular Biology
Glycoproteins
Clusterin
medicine.disease
Cortex (botany)
Frontal Lobe
Endocrinology
Solubility
Case-Control Studies
biology.protein
lipids (amino acids, peptides, and proteins)
Alzheimer's disease
Apolipoprotein J
Molecular Chaperones
- Language
- ISSN
- 0169-328X
This study examines the relationship between the levels of apolipoprotein E (apoE) and apolipoprotein J (apoJ, also designated as clusterin) as a function of apoE genotype in the hippocampus and cortex of Alzheimer disease (AD) subjects. These two lipophilic proteins which are involved in the maintenance of lipid homeostasis are both synthesized in the brain by astrocytes. Results indicate a reduction of apoE levels in the hippocampus and frontal cortex that is proportional to the apoE4 allele dose. Conversely, apoJ (clusterin) levels were found to increase proportionately to the number of apoE4 allele dose. These results suggest a compensatory induction of apoJ (clusterin) in the brain of apoE4 AD subjects showing low brain levels of apoE.