Influence of antiretroviral therapy and cardiovascular disease on the immature platelet fraction in patients living with HIV
- Resource Type
- Authors
- Alexander Goedel; Christiane Schwerdtfeger; Alexander Zink; Sebastian Noe; Dario Bongiovanni; S Müller; Isabell Bernlochner; Bernhard Haller; Christoph D. Spinner
- Source
- Platelets. 31:756-762
- Subject
- Adult
Blood Platelets
Male
0301 basic medicine
Human immunodeficiency virus (HIV)
HIV Infections
Inflammation
Disease
030204 cardiovascular system & hematology
Immature Platelet
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Platelet
In patient
Prospective Studies
business.industry
virus diseases
Hematology
General Medicine
Middle Aged
respiratory system
Antiretroviral therapy
respiratory tract diseases
030104 developmental biology
Anti-Retroviral Agents
Cardiovascular Diseases
Immunology
Female
medicine.symptom
business
- Language
- ISSN
- 1369-1635
0953-7104
Cardiovascular disease is an important contributor to morbidity and mortality in people living with HIV . The immature platelet fraction (IPF) is increased in HIV-negative patients with cardiovascular disease and evidence suggests that an enlarged IPF is associated with adverse cardiovascular events. In this multi-center observational study, we aimed to investigate how the IPF in people living with HIV is influenced by antiretroviral therapy and cardiovascular disease. Subjects without cardiovascular disease that received antiretroviral therapy showed a smaller IPF accompanied by lower D-dimer and C-reactive protein (CRP) levels compared to therapy-naïve subjects (mean IPF: 2.9% vs. 3.9%