Immune-mediated chorea in a patient with kappa light-chain monoclonal gammopathy
- Resource Type
- Authors
- Roopa Rajan; Ajay Garg; Amrita J Gotur; Rishi Dhawan
- Source
- Annals of Movement Disorders, Vol 3, Iss 2, Pp 112-114 (2020)
- Subject
- Paraproteinemia
Pathology
medicine.medical_specialty
congenital, hereditary, and neonatal diseases and abnormalities
peripheral neuropathy
genetic structures
Cognitive Neuroscience
Neuroscience (miscellaneous)
Immunoglobulin light chain
Malignancy
lcsh:RC346-429
Biopsy
mental disorders
Medicine
chorea
lcsh:Neurology. Diseases of the nervous system
medicine.diagnostic_test
business.industry
Chorea
medicine.disease
humanities
nervous system diseases
medicine.anatomical_structure
Peripheral neuropathy
Neurology
Surgery
Neurology (clinical)
Bone marrow
medicine.symptom
business
immune-mediated
Monoclonal gammopathy of undetermined significance
monoclonal gammopathy of undetermined significance
- Language
- English
- ISSN
- 2590-3454
2590-3446
The objective of this paper was to report on a case of steroid-responsive chorea in a patient with κ light-chain monoclonal gammopathy. In addition to subacute-onset generalized chorea, evidence of peripheral neuropathy in this elderly gentleman led us to investigate for paraproteinemia. We treated the patient with intravenous steroids in view of elevated κ light-chain assay and bone marrow biopsy, suggestive of monoclonal gammopathy of undetermined significance. There was a remarkable improvement of paresthesias and chorea at 6 months follow-up with no evidence of evolution to malignancy at 1 year. Autoimmune chorea is a treatable condition if identified and treated timely.