Emerging roles of ATF2 and the dynamic AP1 network in cancer
- Resource Type
- Authors
- Pablo Lopez-Bergami; Eric Lau; Ze'ev Ronai
- Source
- CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
- Subject
- CIENCIAS MÉDICAS Y DE LA SALUD
General Mathematics
media_common.quotation_subject
Gene regulatory network
Bioinformatics
Article
Unison
medicine
ATF2
Function (engineering)
AP1
Transcription factor
media_common
integumentary system
biology
Applied Mathematics
fungi
Cancer
Patología
purl.org/becyt/ford/3.1 [https]
medicine.disease
CANCER
Activating transcription factor 2
TRANSCRIPTION FACTORS
Medicina Básica
AP-1 transcription factor
Tumour development
biology.protein
purl.org/becyt/ford/3 [https]
Neuroscience
- Language
- ISSN
- 1474-1768
1474-175X
Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis. Fil: Lopez Bergami, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina Fil: Lau, Eric . Burnham Institute for Medical Research; Estados Unidos Fil: Ronai, Zeev . Burnham Institute for Medical Research; Estados Unidos