Can mechanical imaging increase the specificity of mammography screening?
- Resource Type
- Authors
- Hannie Petersson; Magnus Dustler; Anders Tingberg; Håkan Brorson; Sophia Zackrisson; Ingvar Andersson; Pontus Timberg; Daniel Förnvik
- Source
- European Radiology
- Subject
- Adult
medicine.medical_specialty
Breast Neoplasms
Malignancy
Sensitivity and Specificity
Mechanical imaging
030218 nuclear medicine & medical imaging
03 medical and health sciences
Elasticity Imaging Techniques
Breast screening
0302 clinical medicine
Recall rates
Biopsy
Pressure
medicine
Humans
Mass Screening
Mammography
Radiology, Nuclear Medicine and imaging
Breast
skin and connective tissue diseases
Early Detection of Cancer
Mass screening
Aged
Neuroradiology
medicine.diagnostic_test
business.industry
Ultrasound
Interventional radiology
General Medicine
Middle Aged
medicine.disease
Biopsy rate
Radiology Nuclear Medicine and imaging
Sensory Thresholds
030220 oncology & carcinogenesis
Female
Radiology
business
- Language
- ISSN
- 1432-1084
0938-7994
Objectives This study aimed to investigate the effects of adding adjunct mechanical imaging to mammography breast screening. We hypothesized that mechanical imaging could detect increased local pressure caused by both malignant and benign breast lesions and that a pressure threshold for malignancy could be established. The impact of this on breast screening was investigated with regard to reductions in recall and biopsy rates. Methods 155 women recalled from breast screening were included in the study, which was approved by the regional ethical review board (dnr 2013/620). Mechanical imaging readings were acquired of the symptomatic breast. The relative mean pressure on the suspicious area (RMPA) was defined and a threshold for malignancy was established. Results Biopsy-proven invasive cancers had a median RMPA of 3.0 (interquartile range (IQR) = 3.7), significantly different from biopsy-proven benign at 1.3 (IQR = 1.0) and non-biopsied cases at 1.0 (IQR = 1.3) (P