Microglia in neuronal plasticity: Influence of stress
- Resource Type
- Authors
- Jean-Christophe Delpech; Corinne Joffre; Sophie Layé; Agnès Nadjar; Eric S. Wohleb; Charlotte Madore
- Source
- Neuropharmacology
Neuropharmacology, Elsevier, 2015, 96, pp.19-28. ⟨10.1016/j.neuropharm.2014.12.034⟩
Neuropharmacology, Elsevier, 2015, 96 (Part A), pp.19-28. ⟨10.1016/j.neuropharm.2014.12.034⟩
- Subject
- [SDV]Life Sciences [q-bio]
Central nervous system
Cell Communication
Stress
Synapse
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Immune system
Neuroplasticity
medicine
Animals
Humans
Cytokine
030304 developmental biology
Pharmacology
Neurons
0303 health sciences
Innate immune system
Neuronal Plasticity
Microglia
Mood Disorders
Brain
medicine.disease
Neuroimmunology
medicine.anatomical_structure
Mood disorders
nervous system
Catecholamine
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Psychology
Cognition Disorders
Corticosterone
Neuroscience
030217 neurology & neurosurgery
Stress, Psychological
- Language
- English
- ISSN
- 0028-3908
International audience; The central nervous system (CNS) has previously been regarded as an immune-privileged site with the absence of immune cell responses but this dogma was not entirely true. Microglia are the brain innate immune cells and recent findings indicate that they participate both in CNS disease and infection as well as facilitate normal CNS function. Microglia are highly plastic and play integral roles in sculpting the structure of the CNS, refining neuronal circuitry and connectivity, and contribute actively to neuronal plasticity in the healthy brain. Interestingly, psychological stress can perturb the function of microglia in association with an impaired neuronal plasticity and the development of emotional behavior alterations. As a result it seemed important to describe in this review some findings indicating that the stress-induced microglia dysfunction may underlie neuroplasticity deficits associated to many mood disorders.This article is part of a Special Issue entitled ‘Neuroimmunology and Synaptic Function’.