Detection of Circulating Tumor Cells
- Resource Type
- Authors
- Guus van Dalum; Leonardus Wendelinus Mathias Marie Terstappen; Sanne Mutter-de Wit
- Source
- Scientifica, Vol 2014 (2014)
Scientifica
Scientifica, 2014(819362):819362. Hindawi Limited
- Subject
- Oncology
medicine.medical_specialty
business.industry
lcsh:R
IR-94900
Treatment options
lcsh:Medicine
Review Article
Bioinformatics
medicine.disease
Metastasis
Text mining
Circulating tumor cell
Internal medicine
medicine
lcsh:Q
METIS-304908
General Agricultural and Biological Sciences
business
lcsh:Science
General Environmental Science
- Language
- English
- ISSN
- 2090-908X
The increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells shed into the blood during metastasis may satisfy this need. Here we review the CellSearch technology used for the detection of circulating tumor cells and discuss potential future directions for improvements.