Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures
- Resource Type
- Authors
- Marie Essig; Guy Touchard; Eve Vilaine; Aymeric Couturier; Elyanne Gault; Ziad A. Massy; Sihem Kaaki; Jean-Michel Goujon; Mathilde Dargelos; A.-M. Roque-Afonso; Sophie Ferlicot; Cecile Ory
- Source
- Clinical Kidney Journal
- Subject
- medicine.medical_specialty
kidney disease
030232 urology & nephrology
urologic and male genital diseases
Gastroenterology
03 medical and health sciences
0302 clinical medicine
angiotensin-converting enzyme 2
Internal medicine
Biopsy
Exceptional Case
medicine
AcademicSubjects/MED00340
Transplantation
Kidney
Proteinuria
electron microscopy
medicine.diagnostic_test
biology
SARS-CoV-2
urogenital system
business.industry
Acute kidney injury
COVID-19
Angiotensin-converting enzyme
Kidney Glomerulus
medicine.disease
female genital diseases and pregnancy complications
tubular proteinuria
medicine.anatomical_structure
Tubular proteinuria
Nephrology
biology.protein
medicine.symptom
business
Caucasian patient
Kidney disease
- Language
- ISSN
- 2048-8513
Background The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI). Methods Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated. Results All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining. Conclusions The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.